Evidence-Based Healing Protocols

Improve Gut Health Editorial Team • Jan 15, 2026 • 15 min read

Step-by-step protocols for Leaky Gut, SIBO, Candida, and Constipation. Includes specific supplement dosages and phases.

Quick answer

A good gut-healing plan looks less like a "detox" and more like a checklist. First, rule out problems that need medical treatment. Then build a baseline routine that stabilizes symptoms. Only after that does it make sense to add targeted protocols.

  • Start with safety: red flags, basic labs, and rule-outs matter.
  • Build a baseline: regular meals, adequate protein, fiber as tolerated, sleep, movement.
  • Target the driver: constipation, reflux, SIBO, histamine issues, inflammation all need different tactics.

Step 0: When you should not self-treat

  • Blood in stool or black stools
  • Unexplained weight loss
  • Persistent vomiting, dehydration
  • Anemia, persistent fever
  • New severe symptoms

A simple phased framework (4R style)

  • Remove: reduce clear triggers and irritants (often alcohol and ultra-processed foods; sometimes specific intolerances).
  • Replace: support digestion when needed (meal timing, chewing, sometimes enzyme support under guidance).
  • Reinoculate: food diversity and, for some people, targeted probiotics.
  • Repair: sleep, stress recovery, and nutrition that supports the gut lining over time.

Common symptom patterns and practical next steps

If constipation is the main problem

  • Hydration and daily movement
  • Fiber increases, slowly (or different fiber types if one makes you worse)
  • Magnesium may help some people, but check with a clinician if you have kidney disease or take interacting meds

If diarrhea is the main problem

  • Rule out infection and inflammatory disease if persistent
  • Check for lactose intolerance or other clear triggers
  • Consider whether high caffeine, alcohol, or very high FODMAP meals are contributing

If bloating is the main problem

  • Look for patterns: after meals, with certain carbs, with stress, with late eating
  • Consider SIBO if bloating is strong and consistent after fermentable foods
  • Address constipation first if present (slow transit can drive bloating)

Supplements: keep it simple and safe

Supplements can help, but they are not a substitute for diagnosis or basic routines. If you use them, add one at a time and track the result.

  • Barrier support: nutrients like glutamine or zinc carnosine are sometimes used, but they are not magic bullets.
  • Probiotics: helpful for some people, irritating for others (especially with histamine issues or active overgrowth symptoms).
  • Antimicrobials: best used with clinician guidance, because the wrong tool can worsen symptoms.

Medical disclaimer: Educational content only. Talk to a clinician if symptoms persist or you have red flags.