Zonulin and Intestinal Permeability

Zonulin role in regulating intestinal tight junctions and its use as a permeability biomarker.

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Study Overview

This pivotal study explores the role of zonulin, a protein that modulates permeability of tight junctions between cells of wall of digestive tract. It was discovered by Dr. Alessio Fasano and his team.

Key Findings

  • Zonulin is the only known physiological modulator of intercellular tight junctions.
  • Upregulation of zonulin leads to increased intestinal permeability (Leaky Gut).
  • Gliadin (a protein in gluten) and bacteria are two powerful triggers for zonulin release.

Clinical Implications

Testing for Zonulin levels can be a useful biomarker for assessing intestinal permeability. However, it is important to note that levels can fluctuate.